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A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants

Author summary The emergence of artemisinin-resistant malaria parasites, first in Southeast Asia and more recently East Africa, highlights the urgency to identify and optimize chemotypes with antimalarial activity that are not compromised by known re

By: Plos.org

Nov 21 2024
6
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A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants — A novel 4-aminoquinoline chemo

Abstract Artemisinin-based combination therapy (ACT) is the mainstay of effective treatment of Plasmodium falciparum malaria. However, the long-term utility of ACTs is imperiled by widespread partia… [+73748 chars]

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Veea, O.N.E. Amazon, and AECOM Collaborate to Create the Internet of Forests (IoF), a Hybrid Edge-Cloud Computing Solution to Protect the Rainforest Biome and Empower Local Communities